Successful PhD dissertation defense
Our colleague, Zsófia Császár successfully defended her PhD thesis on September 25, 2024. Research topic: Synthesis, coordination chemistry and catalytic application of novel chiral aminoalkyl-phosphine ligands Qualification: summa cum laude Supervisor: Dr. József Bakos (DSc, Professor Emetitus) Congratulations! Facebook X Linkedin Whatsapp Telegram Viber
Asymmetric Hydrogenation of Ketones by Simple Alkane-Diyl-Based Ir(P,N,O) Catalysts: A Comparative Study
Zsófia Császár, Mária Guóth, Margit Kovács, Attila C Bényei, József Bakos, Gergely Farkas Molecules 2024, 29, 3743. https://doi.org/10.3390/molecules29163743 The development of new chiral ligands with simple and modular structure represents a challenging direction in the design of efficient homogeneous transition metal catalysts. Herein, we report on the asymmetric hydrogenation of prochiral ketones catalyzed by the iridium complexes […]
Conference participation
The members of our research group participated in a national Chemist’s Conference in Eger in June 10-12, 2024. The topic covered a wide area: synthetic organic chemistry, heterocyclic chemistry, chemistry of natural organic compounds, elemental organic chemistry, catalytic chemistry, green chemistry, selective syntheses, optically active compounds, flow chemistry, bioactive compounds, medicinal chemistry, mechanisms, theoretical and […]
Catalyst- and excess reagent recycling in aza-Michael additions
Catalyst- and excess reagent recycling in aza-Michael additions Lilla Maksó, Boglárka Szele, Dávid Ispán, Ágnes Gömöry, Sándor Mahó, Rita Skoda-Földes Organic & Biomolecular Chemistry, 2024, 22, 2465-2473; https://doi.org/10.1039/D3OB02073H 16α-Azolyl-pregnenolone derivatives were prepared via 2-butyl-1,1,3,3-tetramethylguanidine (n-Bu-TMG) catalysed aza-Michael addition of 16-dehydropregnenolone (16-DHP) carried out in [bmim][BF4]. The application of the guanidine base and the imidazolium ionic liquid made […]
Ruthenium complexes of new chiral phosphine-amine-ether ligands (Ru-PNO) for asymmetric hydrogenation – the role of backbone chirality in pincer ligand design
Zsófia Császár, Zsanett E. Pőrgye, Evelin Tóth‐Farsang, Margit Kovács, Attila C. Bényei, József Bakos, Gergely Farkas Applied Organometallic Chemistry, 2024, 38(3), e7379, https://doi.org/10.1002/aoc.7379 New chiral phosphine-amine-ether (PNO) ligands of the general formula Ph2PCH(R1)(CH2)nCH(R1)N(R2)CH(R3)CH2OMe, where R1, R2, and R3 = H or Me, n = 0 or 1, and their ruthenium complexes of the type [RuCl2(PPh3)(PNO)] have been synthesized. The coordination compounds were […]
Urea-Functionalized Heterocycles: Structure, Hydrogen Bonding and Applications
Urea-Functionalized Heterocycles: Structure, Hydrogen Bonding and Applications Soma J Keszei, Márk Váradi, Rita Skoda-Földes Molecules 2023, 28(23), 7757; https://doi.org/10.3390/molecules28237757 Ureido-heterocycles exhibiting different triple- and quadruple H-bonding patterns are useful building blocks in the construction of supramolecular polymers, self-healing materials, stimuli-responsive devices, catalysts and sensors. The heterocyclic group may provide hydrogen bond donor/acceptor sites to supplement those in the […]
Diols Speed Up Guanidine Base Catalyzed Claisen‐Schmidt Condensation to Produce New 15‐Arylidene Steroids
Dávid Ispán, Áron Küzdő, Máté Fonyó, Ágnes Gömöry, Nikolay Tumanov, Johan Wouters, Sándor Mahó, György Lendvay, Rita Skoda‐Földes European Journal of Organic Chemistry, 2023, 26(34), e202300560, https://doi.org/10.1002/ejoc.202300560 Considerable acceleration was observed in the guanidine-base catalysed Claisen-Schmidt condensation of benzaldehyde and a 17α-methyl-18-nor-5α,13α-androstan-16-one (1) in the presence of ethylene glycol. Rate-enhancement effects of various alcohols and […]
Synthetic methods towards steroid-ferrocene conjugates
Márk Váradi, Rita Skoda-Földes ARKIVOC: Online Journal of Organic Chemistry, 2022, Part III., 1-43. DOI: 10.24820/ark.5550190.p011.885 Steroid-ferrocene conjugates, in which a steroid skeleton is connected directly or via a linker group to the ferrocene moiety, have a broad scope of possible applications in medicinal or analytical chemistry as well as in materials science. They may […]
Synthesis of Novel Ferrocene-Benzofuran Hybrids via Palladium-and Copper-Catalyzed Reactions
Enikő Nagy, Márk Váradi, Zoltán Nagymihály, László Kollár, Krisztina Kovács, Kitti Andreidesz, Ágnes Gömöry, Nikolay Tumanov, Johan Wouters, Rita Skoda-Földes Inorganics 2022, 10(11), 205; https://doi.org/10.3390/inorganics10110205 The combination of the ferrocene skeleton with pharmacophores often leads to molecules with interesting biological properties. Five ferrocene-benzofuran hybrids of different structures were synthesized by transition metal catalyzed reactions. The efficiency of both […]
Synthesis of 3-Aryl-and 3-Alkynylbenzofurans in the Presence of a Supported Palladium Catalyst
Enikő Nagy, Zoltán Nagymihály, László Kollár, Máté Fonyó, Rita Skoda-Földes Synthesis 2023, 55(01), 131-140, DOI: 10.1055/a-1914-0423 Suzuki and Sonogashira coupling reactions of 3-iodo-2-phenylbenzofuran, leading to the corresponding 3-aryl- and 3-alkynyl derivatives, respectively, were carried out using a silica supported pyridinium ionic liquid-based heterogeneous catalyst. Under optimized reaction conditions, arylboronic acids with either electron-withdrawing or -donating substituents as […]